Can't Left click with mouse, works fine otherwise

Started a week ago, when I couldn't double click to open icons. I could Right click and select open, or use the start menu. But now it is a big deal because I have to download a program for work, but I can't click on the box saying I agree to the agreement before I do the download. It's a logitech cordless mouse. I've changed the batteries. I've restarted computer. Under device manager, says mouse working properly. I tried system restore. Not sure what to do next. The R click and cursor part work, so I know it's recognized. I had a hard time booting up last week and was hitting alot of the F buttons on top if that helps at all. I'm not real good dealing with bios, registry or safe mode, so you may have to dumb down your explanations, so I can figure it out. ThanksStarted a week ago, when I couldn't double click to open icons. I could Right click and select open, or use the start menu. But now it is a big deal because I have to download a program for work, but I can't click on the box saying I agree to the agreement before I do the download. It's a logitech cordless mouse. I've changed the batteries. I've restarted computer. Under device manager, says mouse working properly. I tried system restore. Not sure what to do next. The R click and cursor part work, so I know it's recognized. I had a hard time booting up last week and was hitting alot of the F buttons on top if that helps at all. I'm not real good dealing with bios, registry or safe mode, so you may have to dumb down your explanations, so I can figure it out. Thanks

 

Use a wired mouse and post if it works properly. (I always keep spare mice both PS/2 and USB around to test. Mice do die).