Recommended protection/optimization programs

I'm going around to many sites where I trust the information, particularly when it comes to protecting my computer, and asking for a list of recommended protection programs. This includes registry cleaners, cache cleaners, anti-maleware, anti-spyware, defraggers, anti-virus, firewalls, and various scanners and other optimization programs. Normally I would simply go to one specific site I've used before to save my computer from the brink of death, but since this time I'm doing this to help protect someone else's computer, I'm asking everyone and will weigh the answers I get against each-other.

For the record, the programs I've been recommended before are listed below, most of which (unless noted) I use right now either constantly or regularly depending on if they're on-demand protection or not. I will also list the current programs the other person uses after my personal list. All programs are completely free or at least the free version, and please keep in mind neither I nor the other person I'm helping can afford to purchase protection programs. Also, the other person wishes to clean and protect several computers in their household, varying from XP to Vista. I personally run XP.

Recommended to me from various sources

Currently on my computer
avast! Antivirus
Malewaerbytes' Anti-Maleware
SpywareBlaster
CCleaner
Puran Defrag
Housecall
HiJackThis!
Windows Firewall
Gamebooster

Not on my computer, but used in the past or recommended
Webroot Desktop Firewall
Outpost Free
SUPERAntiSpyware
ComboFix
OTL

On the other person's computer
Ad Aware
AVG
NOTE: I have mentioned to the person in question that having two anti-virus programs can cause problems, however he insists that that's not doing anything. Still, the more people mention it the more I have to show him proof lol.
Malewarebytes' Anti-Maleware
Spybot S&D
Uniblue Speed Up My PC

Recently recommended by a friend
Peer Protector

It would be best if the programs recommended are user friendly and don't need much guidance to learn. The person in question has a 2 year degree in networking, however he rarely bothers to keep things maintained unless they are showing obvious problems, hence him asking me to help him out like this.

I will also update whenever I receive more recommendations and cite the source (whenever applicable, certain sources I wouldn't want to advertise due to various site rules).

Any opinions on the above programs or other programs are welcome. I hold no bias towards or against anything, so please share any experience you have. If anyone has any questions as to what any of the above programs are for, feel free to ask. I am not sure whether the programs listed are well known or not, I only know what I have used and what has been recommended to me.

Below I will list a few of the answers I've gotten from Yahoo Answers so far. I do not recommend clicking any links posted, as I have not investigated them yet myself. Also, I'm not editing the answers I quote at all, so forgive any horrendous grammar or spelling. Each quote is a separate answer.

Spoiler

 

Ah alright, I wasn't sure whether this was the right place, and I didn't want to post it twice. I'll post it again in the software section in a bit then.

As for yahooanswers, I've gotten some decent information from it, but since this is something high profile as it is, yahooanswers is at the bottom of my priority list. Hence my posting the answers I got here, that way more expierienced and trustworthy people can verify or counter these solutions before I recommend them