Some simple questions about malware removal

Hello everyone-

Long time guest, new time registerer

I just recieved a virus/trojan on my computer from a friends drive. I've gone through the read and run me first, but they seem to keep coming back. But I digress. My problem is I cannot use combofix or mgtools because I run Vista 64 bit. So my questions:

Are there any similar programs such as combofix? MGTools?

And a stupid questions...will reformating my drive permanently get rid of these virus/trojans?

Thanks everyone!