Used IObit to delete program, should delete registry items also?

I used IObit to delete my newly installed Spyware Blaster which would not open.

After the initial deletion, a window came up that asked if I wanted to delete other items left behind:

"1723 items
1720 items in registry
and 3 items in Program Files"

I was afraid to delete the registry items, but should I do that in the future? I cannot bring those up again, of course.

Second question, installed Spyware Blaster twice and both times the program would not open no matter where I tried to open it from.

Any suggestions?

Thanks, Mishkyn

 

Dear Kestrel,
Thank you for your quick response, which I so appreciated.

I think I discovered the trouble for SpyBlaster not opening--I should have checked this first before bothering you:

Found this on the Wilders Security Forum:

"SpywareBlaster 5.0 has been released!
New in this version:
Google Chrome support"

That must be why it did not open.

Just one more question if you could help:

When IObit removes a program, then offers to finish off more of the program removal by offering to remove a few more items including 1720 registry entries, should I let it remove things from my registry?

I am always so frightened about tampering with the registry, and would greatly appreciate your advice and expertise.
Thanks, Mishkyn