Virtual Memory Loss/Explorer not loading

Hey all,
Recently started having some trouble with my computer. When I restart and log in, explorer usually won't load til the third or forth restart, or rather it freezes in the processes tab, though killing it and running it doesn't load it either. Also, when I simply leave explorer open and walk away for some time, the lack of virtual memory pops up. This combined with major slowdown at times to the point of my having to restart repeatedly is extremely annoying. I run Spybot, Adaware and Microsoft's Windows Defender often, along with WinPatrol, which didn't say anything until that some changes have been made to file I have no idea about, in C:/Windows. One other note is that once or twice in the past month when I've started up, Windows says that it can't find a slave drive, but that hasn't happened very often, and a restart has it stop complaining.

So, thanks for any help, I apologize for being spotty on the details of messages, but I'll try to recreate anything if needed, as I'm extremely tired of this.

Hijack This log:

Edit by chaslang: Inline HJT log removed. READ & RUN ME sticky not followed.

Thanks again,
Squeaks