Vista not saving settings

I'm running 32bit vista sp1 and having some problems

Every time I shut down vista and reload it in the morning, I have to go into the control panel and set my mouse speed again. It keeps reverting back to the default setting.

Another thing is my RK Launcher setting have been restored to default and my custom icons are gone (drag and dropped shortcuts basically).

Any ideas?

Edit: I should mention that everything else is fine and strongly believe my computer is virus free. I just think I have a setting off, but i can't figure out what it would be....

 

any help guys?