Major problems on IBM ThinkPad T41

My system has slowed considerably in the last two weeks; I have always had Spybot, Spyware Blaster & Adaware on it and well as Stinger and update/run them regularly. I also use Spydoctor which seems to find a few that aren't found by the others. Last week I scanned online at Norton's site and also downloaded new version of McAfee. After full scans for a week or so, had to remove all mcafee products, taking up too much ram on top of already existing problems, was impossible to get anything done. No scans reveal anything, however, I'm get a lot of errors lately, mostly unable to read/write.. referencing a particular location... not always the same. Ran memory checks by using pc doctor.. lots of errors there too. Don't know if it's memory, hard drive damage or spyware at this point. I can't seem to run more than two apps at a time w/out coming to a halt and hd spinning for 20-30 minutes, ctrl/alt/delete don't always remedy that either. I use Hijaack this from time to time, I came here and read the requirements before posting log.. downloaded other apps suggested & installed and/or ran. Nothing found. What I can tell you is this; adaware stops functioning when hitting a particular registry entry, which i found in regedit to refer to something called dxlutbuilder.. can't locate on web what this is for, haven't edited naturally, and spydoctor stops working entirely when hitting a particular file - oledb32.dll. Do I just replace file from backup or is this indicative of a larger problem.. There seem to be so many at this point. I don't know what else to do at this point.. any ideas?