Ai (artifical Intelligence) In Medical Diagnosis, Would You Trust?

Discussion in 'The Lounge' started by DavidGP, Dec 1, 2018.

  1. DavidGP

    DavidGP MajorGeeks Forum Administrator - Grand Pooh-Bah Staff Member

    Coming off a two day meeting I was in, this past week, and most of Friday was on AI in medicine, comes the question would you trust a PC to give you your diganosis over a human doctor?

    I'm for it but AI has a ways to go and for below points for me.

    1. Great for screening disease vs no disease, in ophthalmology this can be achieveable
    2. Would need to me multi-modal as in we use various imaging to determine a eye condition, Colour Fundus, OCT/OCT-A, FFA and ICG imaging, AI would likely need to know/learn features of various conditions from multiple imaging.
    3. Part issue is blood in a retina, does not likly always to one condition, it can be multiple, so would have to learn patterns and type.
    4. Would you trust a machine?

    A question and not medical for me was if anutomamous car (we are going this way more these days) can predict or see an accident about to happen, is its main core programming to protect the occulant (owner of car) or if it sees a pedestrian/cyclaist or other car who does it save?


    Some papers info on topic
    http://groups.csail.mit.edu/medg/ftp/psz/SchwartzAnnals.html
    https://www.cnbc.com/2018/06/28/babylon-claims-its-ai-can-diagnose-patients-better-than-doctors.html
    https://www.techemergence.com/machine-learning-medical-diagnostics-4-current-applications/
    https://www.techemergence.com/machine-learning-healthcare-applications/
     
    Last edited: Dec 1, 2018
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  2. Replicator

    Replicator MajorGeek

    I think its grand that we are utilizing modern Tech in order to better understand what we are up against!

    But I still think that human intervention is completely necessary, and should never be underestimated.
     
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  3. joffa

    joffa Major Geek's Official Birthday Announcer

    I think AI in medicine is a great idea and it can be utilised to perform mundane tasks and analysis to free up the specialist's time enabling him/her to spend more time on cases that are much more complicated or have other factors at play requiring consideration beyond the scope of a machine program.

    Of course if it was me I would be happy for the machines to do their thing so long as at some stage, if a problem is discovered/encountered, there is a review by a qualified specialist. Diagnostic tests are pretty easy as most are a no problem or problem at some level and analysing test data, the machines will generally be far more consistent than a human but humans excel when there are a few shades of gray because humans can quickly see the bigger picture.

    Here is, I think, a very important point even if the AI/machines could be demonstrated to be 99.9% effective and reliable, if you were one of the affected 0.1% failures then nothing would make you happy about the failure because you may have to live with or die because of this failure. So if machines are doing surgical procedures then I think there should be some oversight by humans........off on a tangent.........we have a national health system here in Australia and you can imagine how happy the government would be to reduce the number of surgeons/specialists on the payroll so you need to temper this adoption of automation as a clinical improvement against adopting it as an economic cost cutting measure. The real problem would occur when politicians driving economic savings will say they will cut healthcare funding unless AI is adopted regardless and even though some patients would have a worse outcome the politicians would still be happy because of the savings realised.

    As a diagnostic tool AI is already invaluable and is getting better at an astonishing rate and I think soon there will be the equivalent of robot doctors at some level within my lifetime. Many of the tests that were done on me in the 1990s by doctors are now done by machines although I don't get to speak with them...............hmmm some of them have a similar bedside manner to a couple of my doctors.
     
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  4. Just Playin

    Just Playin MajorGeek

  5. Eldon

    Eldon Major Geek Extraordinaire

    I can testify to that. :)

    Last year, 11 days after a triple CABG, waking up, the top third of my vision from the right eye was black. A few days later the cardiologist booked me for appointments at an eye clinic, neuro clinic, as well as a CT scan. At a second visit to the eye clinic the ophthalmologist diagnosed optic neuritis.
    And then, the results from the CT scan ruled out optic neuritis. The neurologist and head of the neurology department decided to rely on the diagnoses of the relatively young ophthalmologist even though I'm highly unlikely to contract optic neuritis. I was treated with steroids every day for 5 days. Within 2 days my field of vision improved.
    Thankfully there was no shrinkage...:p

    While the above isn't AI it's an example of how indispensable real doctors are. More so considering an ophthalmoscope is a relatively simple machine compared to a CT scanner and it's related equipment.

    For those interested...
    Optic Neuritis
    https://www.webmd.com/multiple-sclerosis/optic-neuritis-ms-vision#1
     
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  6. baklogic

    baklogic The Tinkerer

    Much as machines can be very helpful, the end answer for me is- can I see a proper doctor, or peace of mind.
     
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  7. DavidGP

    DavidGP MajorGeeks Forum Administrator - Grand Pooh-Bah Staff Member

    @joffa "Of course if it was me I would be happy for the machines to do their thing so long as at some stage, if a problem is discovered/encountered, there is a review by a qualified specialist."
    Thats where I'm at with this and many in AI community are also, it can be a great tool for disease no disease screening but when an issue is found you still at this point need an expert.

    @Eldon indeed Imaging and scans will tell us loads of info and as you well know eye scans give huge amounts of info as to whats going on but still need an expert to review as many things can look similar, its differentiating the subtleties thats the key.

    @baklogic hence my question, as I got this from comments and questions in the talks I was in last week on AI in medicine, we dont trust a machine as yet, even though they maybe better, but the human interaction with results to medical tests is still needed.

    I'm always going to be involved with AI in ophthalmology as I think its a future game changer to diagnosis as I see too many false positives these days that do add to waiting times and clinic numbers, if we can slim that down to who needs to be seen then medicine becomes more efficient.
     
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  8. joffa

    joffa Major Geek's Official Birthday Announcer

    Something just in........my 88yo mum has a friend that has started to have problems with her eyes and she was telling mum that she doesn't know what to do because she keeps getting her glasses changed but it wasn't really helping. Mum suggested she get a referral to the same specialist eye clinic that successfully repaired my detached retina last year.
    Long story short she didn't think it would do much good because she had been seeing her eye specialist in country Victoria for over 30 years (turns out he was only an optometrist).
    She ended up getting a referral and they did a whole range of tests using their high tech scanners and machines. As I mentioned previously to DavidGP in a PM when I had my surgery, this clinic has some of the highest tech equipment in Australia so my mum's friend was really surprised that most of the tests were done by machines with a young operator and was thinking that the machines might not be up to the task. She was therefore surprised that after a battery of tests and then a couple of repeat tests to double check the results, she was ushered in to speak with two ophthalmologists. They told her she had glaucoma and there was something they could do to help and suggested surgery as soon as possible. Three days later she had the surgery and has had a very good outcome.
    She thanked my mum for giving her the info on the clinic and she now thinks the machines do a great job so is a convert for technology.
     
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  9. DavidGP

    DavidGP MajorGeeks Forum Administrator - Grand Pooh-Bah Staff Member

    Joffa

    Yeah its a problem here as well, thinking vision is not great and having new glasses that dont help, TBH the opticians prescribing need struck off, especially if they dont check via slitlamp or retinal imaging (OCT is preferred these days but nost opticans dont have them as expensive). I always advise patients who I find with no issues to basically use real worl things like a door frame or any straight line to see with closing one eye at a time, if the lines are bent! if so get eyes checked, also if have a dark patch (scotoma) in an eye get that checked also.

    Fantastic result and yes the scans can be taken by experienced techs not opthalmologists, its the end resulting scans that need the interpriting into what eye condition it could likely be, this generally done by an ophthalmologist, this is where I think AI comes in to screen positove vs negative then any positves are passed on to an clinician.

    Great outcome for your mums friend and now she will likely pass on the info to others, thus helping them.
     
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  10. joffa

    joffa Major Geek's Official Birthday Announcer

    Thanks for the extra info Dave :):cool:
    The hardest part was mum convincing her to come into town to have it checked out. Mum's friend lives over on the east coast of Victoria (near Lakes Entrance) and it is a 4 hour drive to the big smoke...........she was thinking if there was a problem her optometrist would surely know but as it turns out the optometrist was just in the business of selling new glasses.
    Lucky my mum is fairly "au fait" with eye problems and when her friend said that the venetian blinds were no longer straight and the doors on her cupboards looked warped........that's when my mum became insistent on a proper eye specialist. Luckily her friend listened because the specialists said another few months and the surgery wouldn't have been as successful and she would have had ongoing problems. After the surgery she was given the all clear and she just has to take some pills until her next review.

    Yes now she is a convert to high tech, she is telling all her friends to get checked out where ever they have modern test equipment.
    Out in rural areas where the doctors have a smaller patient base investment in expensive test equipment is not a priority and is seen as a luxury investment they can manage without. Of course this will slowly change as the equipment gets more affordable. :cool:
     
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  11. DOA

    DOA MG's Loki

    It's not either or, they need to work together. The problem is usually the human even when they are right. People don't like to be questioned. That will be the ongoing challenge, can the human doctor accept the help an AI doctor can provide?
    On a side note, while not AI, our latest doctor not taking good advice problem. Wifey needed pills, doctor gave her a prescription, nurse mentioned that dose was rare in a single pill and recommended two pills a day of half the dose. Doctor gave her a stern look and she left. A month later we needed to reduce the dose and had to toss $350 in pills as the manufacturer does not allow cutting them. We bought the same pill the nurse recommended originally to cut the dose in half. The doctor maintains he did the right thing.
     
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  12. harmless

    harmless Staff Sergeant

    i would hope that its primary objective would be crash avoidance. if that is not possible, then a series of decisions would need to be made. people inside of cars have built in protection, so the priority should be saving ( not crashing into ) the pedestrian/cyclist. the car should be programmed to either crash into another car or other stationary solid object. cars and objects can be repaired or replaced, humans can not be just switched out/easily repaired/completely replaced.

    back in october, one week after my 60th birthday, i was on the freeway in stop and go traffic. i was stopped, looked up in the rear view mirror, only to see the car behind me, going really fast, and rear ending me with enough force to push me into the car in front of me. my gut feeling is that in a moment of panic, he stomped on the gas pedal instead of the brake. we were both injury free, but his car was totaled and my car was totaled.

    anyway, autonomous cars should protect the pedestrian/cyclist first and foremost. and maybe it is just me, but until they can program autonomous cars to deal with rain, sleet, hail, high wind gusts, snow, flurries, freezing rain, landslides, potholes, etc etc [ every single weather condition imaginable ] i don't ever want to own one. but then, i am old and cranky :)
     
  13. DavidGP

    DavidGP MajorGeeks Forum Administrator - Grand Pooh-Bah Staff Member

    @joffa -
    This is where folk like your mum are invaluable, as quick diagnosis and treatment can be key to keeping vision stable or better.

    @DOA -
    Indeed thats my query on AI can human accpet be it doc or patient the advice of a AI... personally I think we could in some instances, but we do still need check and balance and basically QC on the results so maybe 1 in 100 cases or less checked for accuracy. Your 2nd part also shows is human doc right as an AI wouldnt care for costs, just look for evidence based outcome which was best for you.

    Personally in any diagnosis I make I weigh up the differentials and likely outcome, at times er on cautious side and do further tests and one is invasive but dynamic so will give an extra level of accuracy to diagnosis in a Fundus fluorescein angiography (FFA) test, personally in the referrals I get from opticians for wet AMD I only do 28% of the patients with an FFA as the earlier OCT and Colour images enough to know whats going on.

    @harmless - thats the big issue in that if the AI or car knew the outcome of a crash severity it could determine the occupants % of survival and act accordingly, but if it cannot does it protect the owner/occupants over others, a moral judgmnent an AI likely cannot make at present.
     
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  14. harmless

    harmless Staff Sergeant

    from my "humanitarian" viewpoint, protecting the pedestrian/cyclist, should be primary, first and foremost. however, the large corporations, who are writing the software, would probably prefer to protect their property ( car/software ) over those annoying humans, since all we do is cause problems and keep them from making money.

    it will probably come down to something similar to how worker's compensation insurance works, in that.... i used to do bookkeeping for a company that employed iron workers and built buildings. worker's comp insurance for iron workers erecting buildings 3 stories and under was incredibly expensive compared to buildings over 3 stories. basically, someone falling off a building over 3 stories would die, and all the insurance had to do is pay out death benefits. if the same worker fell off a building under 3 stories, he would most likely survive, but then the insurance company would be on the hook for his medical care for the rest of his life, and that could get really expensive.

    so, unless compelled by law, i see those autonomous car corporations taking a similar viewpoint. basically : humans are costly, property is not.
     
  15. DavidGP

    DavidGP MajorGeeks Forum Administrator - Grand Pooh-Bah Staff Member

    I can see your point but I disagree in part not fully as its a judgment call of self presevation.

    Why should an AI derived car 100% think of saving the pedestrian or cycalist over the occupant of the AI car? I know its a judgment thing but is the AI thinks 70% say the occupant is going to be ok, then save the other, if the occupant is less % then where do we go, never going to sell AI derived cars or transport if its not going to look after the occupant.

    I agree with your Iron workers story. However this in AI comes down to what does the AI and we are heading for AI to be judgmental in their thinking and outcomes, what do they choose? In medicine and this I'm heavily involved with of last few years in that AI and neuralnets and great for some diagnositic tests to give us ideas on severity or a positive diagnosis, its not great with all eye conditions yet, but this is where AI needs alot of training and more so data, small sample sizes of 1000 say images of an eye are not great it needs 10K+ in which we do have a data set on one UK wide study on population health we have and this is 65K so needs the AI algorythm to be fine tuned to various eye conditions to train it.
     
  16. Replicator

    Replicator MajorGeek

    Thats the problem.........cyclists and pedestrians need to take heed about their own safety. If we continue to place them in the 'Hard done by' bin, then they will continue to not take care at major congestion points, because they can.

    Yes, we should be aware of all road users be it on wheels or afoot, but placing the responsibility upon those who occupy a larger surface will never work.

    Cars are a luxury we know, they are designed to please those willing to pay for the privelage. So Yes, they should absolutely be designed to protect those that fork out for that privilege, not the third-party.
    Why would a multi-million dollar business do otherwise??
     
    Last edited: Dec 22, 2018
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  17. DavidGP

    DavidGP MajorGeeks Forum Administrator - Grand Pooh-Bah Staff Member

    @Replicator agree and onus is self awareness in not just roads but life I guess, I have issues in part with cyclists and not to single them out too much but I am, sadly! in that I agree cyclying is where we need to go more and in UK we have in many cities cycle lanes, brilliant.... not so much as they hardly used as the pavement for pedestrains is, so to beat traffic lights, cyclists hop on pavements, thus adding to the safety issue of pedestrians, my main problem is I work in a hospital as many here know and, see cyclist wizz down street when old/inferm and not so well people walking they dont care, nearly hit by cyclist on a few occasions on pedestrian pavements.

    Could go on about the irrisponsable few without lights etc but we also have irrisponsable car drivers.

    Have no issue with cyclists if obeying law and think we need to cycle more in cities. Would AI traffic flow maps work?
     
  18. Replicator

    Replicator MajorGeek


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