Buffer Overrun Detected

I cannot open IE. I continue to get a pop up that says; Microsoft Visual C++ Runtime Library Buffer Overrun Detected C:\program files\internet explorer\Iexplorer.exe. I can get on line through AOL, but the window comes up periodically. I have ran a deep scan with my anti-virus program, scanned with Ad-aware, Spy Bot Search and Destroy, Hi-Jack This. I tried to do a system scan disk, but it won't work it tries several times then a pop up says that it has tried but is not working etc. Don't know where to go from here as I'm not that computer savvy. Can anyone help???????????????????