Fonts corrupted? Cache?

Fonts corrupted? Cache?
On a new install of Win7 Home Pro all of a sudden the fonts in IE (on webpages) are all italicized and Verizon webmail is all in bold. Word fonts seem to display ok.
I have studied this on Google and it seems a problem which goes back to earlier versions of Windows even to 9x. There seems to be a variety of fixes which have worked but certainly not for everyone. I do this every day and haven’t seen this problem before.
Thoughts on deleting the font cache dll or even replacing the whole fonts folder? Other ideas? I have tried every possible configuration change in Firefox and IE and windows itself. I have reset defaults in the fonts folder all no go.
Ideas?