Desperately Need Help

I'm at my wits end. First Windows Defender said I had something in my computer, it gave me the option to delete and I did it. But Malware Bytes kept detecting something in the quick scan. What I linked was just the most recent one, as every time I rebooted after said scan I did it again only to to find more things, and they varied from 1-3 detected things. To get a second opinion, I tried Avast and OH MAN it CONSTANTLY kept popping up a window saying malware blocked blah blah blah you dodged a bullet great. Their scan also detected bad things and didnt seem to remove them either.

So I went with Combofix (no I didnt get someone to help me out but this isnt a my computer is dead cuz of combofix thread) and after it stalled twice it eventually went through all 50 stages, then SAID it deleted the problem. After it took forever and rebooted my computer then made it's own log (also posted) it wouldnt let me run Malware Bytes (normally doing it in admin worked just fine) and the quick scan said nothing was detected.

Great except that after a new restart all was back as it was before. I actually uninstalled Avast just so it would stop going off. So yes I no longer have any Avast logs. (I think those 2 should suffice right?)

I really just want things to go back to normal, can anyone help me out here?