Help! Something causes me not to click on anything on Windows 7

Everything Works fine but every once in a while I have to "CTRL+ALT+DEL" and then cancel for anything to be clickable on my windows or GUI. I don't know why, but it's really frustrating to do so and I already use the new Kaspersky 2011 anti-virus, Malwarebytes, and Microsoft Security Essentials, are all up-to-date and I used Full-scan with all of them. and there are no viruses detected whatsoever! And my comp seems fine and fast, but something is really doing that! I don't know what's causing this because I alt+tab a lot between programs, but I think some kind of program of some sort or something is preventing me not to click on any programs or anything on the desktop. I think it might be Rainmeter.. but not sure.

I'm not a new person here on the forums, but if anyone can help me I'll really appreciate it! I'm pretty sure the problem is minor though and can be solved easily.
- Thanks.

 

Hmm.. another reason I wonder too is because I have "UAC" off right now which I need to turn it off because I use MotionJoy Drivers in order for my Playstation 3 Dualshock 3 controller to be functional with the analog sticks. I play Final Fantasy XIV by the way which is what I use my playstation 3 controller for.
Any ideas guys? Is it because I have UAC disabled? Will enabling UAC again fix it? I had it off for a month.

 

Malwarebytes generally is a run on demand, so wouldn't be the real issue, i use kaspersky 2011 myself and have noticed some oddities in my system lately but can't pin point anything at the moment, for starts please try to disable either malwarebytes or ms security essentials.

 

Oops, I'm sorry.. yea I already uninstalled Kaspersky and Malwarebytes because they will conflict with other programs. Now I have Microsoft Security Essentials alone installed, nothing else. Anyway, can anyone tell me what is exactly is going on that causes me not to be able to click on any programs or anything on my GUI? I can Alt+tab through programs, but yet none of them are clickable, so there's no use. I have to "ctrl+alt+del" then cancel it, then everything is working just fine again and I can click on anything on the GUI. I can't be doing that all the time though because doing so will crash my "Final Fantasy XIV". Any ideas?

 

Sometimes if you alt-tab out of a game, either windows or the game (I suspect windows) will not fully switch to the other program or the desktop. It will leave the mouse clicks inside the game even though the mouse pointer is on the desktop.

Next time this happens, alt-tab back into the game and then out again.