Laptop full of malware

Hi,

My son-in-law is having problems with his laptop and asked me if I would take a look at it. I ran the usual CCleaner, AdAware and Spybot first.

I also ran Anti-Worm and it found something called a duplicator. It's located in Windows > System32 > drivers > etc. The message said that the original host file was replaced by a replicant, where it replicates itself all through the pc and, when you try to kill it, it will sprout off somewhere else and try to hide.

When I ran Spybot S&D, it found a file named Win32.Autorun in the registry, SBI $DE8B4C73) Settings HKEY_LOCAL_MACHINE\SOFTWARE\MICROSOFT\Windows NT\CurrentVersion\Winlogon\Shell

I was going to attach screenshots but I couldn't find the Prt Scr button on the laptop.

I deleted the Win32.Autorun problem but the problem found by "Anti...worm" gives no methods for removal of malware. It only tells you where it found malware. What would be a good program that would find the replicant and remove it, or is a format of the laptop needed?

Since this is my son-in-law's computer, I'll let him do any further testing and be in contact with you. Any help you can give would be great.