Malware Removal Tools not Opening

Hello Geek Saviors

Am trying to run the Malware Removal Tools for my Acer 2012 Laptop, Windows 7, IE 11, AVG antivirus, Comodo Firewall. Have downloaded the Tools to desktop and followed the Win 7 malware removal directions. Have following problems despite lowering Internet security settings, trying with Comodo Firewall disabled (also Comodo in safe mode) with all tools software entered as safe applications, running in Windows Normal Ops:
1 - Defogger, after clicking DISABLE and YES get immediate red X message "Unable to Create Log"
2 - RogueKiller, right click "run as admin", depending on Comodo settings noted above variably got Alert Triangle "Software is Not Available" or once setup opened and started abruptly disappeared with message "Download Manager has stopped working. A problem caused the program to stop working correctly. Windows will Close and notify you if a solution is available". Tried renaming to "RK.exe" with same result.
3 - Malwarebytes - tried after RogueKiller failure, right click "run as admin", and got exact same response as for RogueKiller.

Did not try other tools. Any idea what I can do to get tools to run? Have not tried computer Safe Mode - would this help?
Thanks for any suggestions and guidance.

 

Thanks Tim and Chaslang for the suggestions. I will try Malwarebytes and RogueKiller in Safe Mode and see if they will run. I need to check and see if any Disk Emulation software is installed (not to my knowledge). I was able to successfully run TDS Killer, Hitman Pro, and MG Tools - those logs are attached. Checking with my IT guy at work, looks like something changed my profile and possibly IE 11 (which was installed by MS on 12/3 and has worked OK until last night). Running AVG antivirus, SuperAntispyware, and Spybot scans found nothing.

 

Hi Chaslang

Thanks for reviewing the info and log files, and identifying the likely problems. This is my personal laptop, not company. I took it in to work so I would have an online ability to do the malware checks with the latest tools. I suspected there was malware because overnight the desktop had changed, some icons were missing, IE was not working, and all favorites had disappeared from IE. I had made no changes myself to the laptop, so suspected I had "caught something" in my browsing. I apologize for thinking this was a malware issue, but I'm not savvy enough to recognize otherwise. I do greatly appreciate the help and the work that you all do, so thanks again.
Bob