Stubborn malware problem

I'm not exactly sure how my computer became infected, but I know that it is.

I use Avira AntiVir as my antivirus program, and I also use HouseCall by Trend Micro for additional protection, as well as eScan (MWAV). Avira AntiVir has found some stuff which I don't remember the name of, but I'm fairly sure that they had "Java"-something in them, thus being Java-based. I preformed a full scan with AntiVir and then it came up clean. However, after an update, it found something called HTML/Dldr.Agen.QV.7 which according to what I heard from another person is a Hungarian keylogging Trojan designed to capture bank account keystrokes. HouseCall found one "grayware" but after that, it has been coming up clean.

However, eScan has found various stuff, among them freespyscannerandremover Corrupted Adware/Spyware, Possible Fujacks-type Worm and zlob Trojan-downloader. These seems to be gone now (at least eScan hasn't refound them), but the malwares called gain.gator and look2me refuse to go away. Multiple times, eScan has identified them and "removed" them, but at a computer restart an eScan scanning finds them again. I've tried the two available anti-look2me programs available here, but Kill2me is unable to identify and remove it, and Look2Me-Destroyer fails to restart as it is supposed to do after the box "Run this program as a task." is filled in. Spybot and Ad-Aware come up clean, I might add.

I may also add that Spy Sweeper has found clientman. However, I'm using the trial version so it won't remove it.

This malware quite often unblock a few sites which Advanced Windows Care has blocked, as well as causing the computer to make a lot of noise (like if it was preforming heavy work) after start-up untill perhaps 5 to 10 minutes afterwards, for no apparent reason. Recently, my IE start page was also changed from the BitDefender Online Scanner to nothing. I use Firefox for general surfing, just using IE for online scanning.

I might also add that I've been unable to scan with BitDefender and Panda (I was following the Read and run me first). When I try to change the settings in the Online Scanner, I get an error message, and if I try to run the scanner, it fails to download the definitions, and warns that any scanning will probably be inaccurate. If I try to run Panda, IE crashes.

Frankly, I also believe that something more sinister has infected me. Why? Because some programs that used to start up at the start, like the Spy Sweeper trial, doesn't anymore, SpywareGuard crashes immediately when the computer starts, etc. From what I've read about look2me and gator, I seems unplausible that they would do such things.

I've also run Norman Malware Cleaner and AVG Anti-Rootkit Free as well as a-squared Free, and they all come up clean.

My OS is Windows Vista.

That's pretty much it I think. Hopefully I haven't forgotten anything, and I hope to get some help here, since no program seems to be able to solve it. I can post a HijackThis log you wish.