Virtumonde/Smitfraud/others PLEASE HELP!!!

Hey everyone. It started with Avast notifying me that I had a virus (Win32.agent.wmrr, I think?). I moved that item to the chest, did a scan, and found nothing else. I later ran Spybot S&D, which found Virtumonde, Smitfraud, and Win32.xxxxx (assorted). I deleted those items, rebooted, and scanned again with Spybot. And lo and behold, everything is back again.

I was getting IE pop-ups (don't know if I still am...I haven't been back online on that computer in some time), and a balloon keeps appearing in my tray telling me that automatic updates have been turned off. When I try to turn them back on through Windows Security, I get an "I'm sorry" message, and when I go to the control panel, it says they're already on. :confused

I want to run the Smitfraud fix, but I have no idea if Virtumonde and Smitfraud are connected, and I don't want to get rid of one only for it to come back because the other is still there.

I see many people referring to something called "Hijack This," but I have no idea what that is.

This is really frustrating, and I'm traveling in a few days so I really need this computer to be in top shape, so I'd really appreciate any help!

 

Okay, so with Malwarebytes, I was able to get rid of mostly everything, and I can now turn on automatic updates. However, I'm still get pop-ups, and Malwarebytes keeps detecting these two keys:

HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\MS Juan (Malware.Trace)
HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\MS Track System (Trojan.Vundo)

MB deletes them, but they reappear upon reboot.

This is really frustrating, and I don't want to give up and do a factory restore on my computer, because I don't have much time. Please help!!! =(