My family computer is a desktop PC running Windows Vista with McAfee. I make sure to run all updates ASAP. My updates are current through yesterday. When I tried to update my computer this morning, the updates failed with an unknown error. "Error(s) found: code 80070103 Windows Update encountered an unknown error" This morning, I turned on the computer to find that McAfee has been disabled, Windows Defender has been disabled, and that I cannot turn them back on. Additionally, I cannot run any programs. Invariably, I get the response "program.exe is not a valid Win32 application" regardless of whether I run the program from the C drive or a USB. Neither Internet Explorer nor Firefox are working; I can only access the internet by opening windows explorer and typing an address into the address bar in that window. I have tried running McAfee in safe mode, but get the same message. I tried the "repair computer" function when I boot the computer, but it insists that I have another drive attached (though I have unplugged the camera, flash drvie, external hard drive)... There is nothing attached (except for the keyboard and mouse). I have tried restoring my computer to a previous restore point only to be told by the computer that there are no restore points. I started Googling and thought that it may be the Bagle virus because of the "is not a valid Win32 application" but found none of the files listed on the Removing Bagle Infections page. I looked at the thread titled “x:\ is not a valid Win32 application” which led me to a dead link: http://support.microsoft.com/Default.aspx?kbid=303395&sd=RMVP . I have read and followed the instructions on the READ AND RUN ME FIRST and Vista Cleaning Procedure threads, but to no avail. I could not download the files on the infected computer, and so I used my personal laptop to download the scans to a flash drive. I plugged the flash drive into the infected computer and tried to run each scan as instructed by the threads. I have no logs to attach as the scans could not run. I took the following notes: Could not open McAfee to empty quarantine folder. “c:\Windows\system32\rundlll32.exe is not a valid Win32 application” Could not run CCleaner. “F:\C Cleaner.exe is not a valid Win32 application” Could not be sure Msconfig was set for normal startup. “C:\Windows\system32\msconfig.exe is not a valid Win32 application” Could not follow Step 4; link to “Uninstall Malware via Add/Remove Programs” did not work Could not download Root Repeal because “The bandwidth or page view limit for this site has been exceeded and the page Could not be viewed at this time. Once the site is below the limit, it will once again begin serving as normal.” Could not install/ run SUPERAntiSpyware. “F:\SUPERAntiSpyware.exe is not a valid Win32 application” Could not install Malware Bytes. “F:\mb.exe is not a valid Win32 application” Could not run/ install ComboFix. “C:\Users\Onixill\Desktop\ComboFix.exe is not a valid Win32 application” and “F:\ComboFix.exe is not a valid Win32 application” Could not run/ install MGtools. “C:\MGtools.exe is not a valid Win32 application” To get a better idea of what I’m dealing with, I ran Kaspersky’s online scanner. It found the following threats: (My apologies for not attaching a log; the report was made on the infected computer and my [limited] experience workign with computers has taught me not to pull something off of an infected computer to put onto a clean one) File- C:\Program Files\2wire\sst\VNC\MotVNC.exe Name- “not-a-virus:RemoteAdmin.Win32.WinVNC-based.b” There are 2 reported objects infected by this virus. File: C:\Program Files\Windows Antivirus Pro\Windows Antivirus Pro.exe Name: “not-a-virus:Fraud Tool.Win32.AntiVirusPro.nf” There is 1 object reported infected by this one. File: C:\ProgramData\19195324\19195324.exe Name: “Packed.Win32.Krap.r” There is 1 object reported as infected by it. File: C:\Users\All Users\19195324\19195324.exe Name: “Packed.Win32.Krap.r” There is 1 object reported as infected by it. File: C:\Users\Onixill\AppData\Local\Microsoft\Windows\Temporary Internet Files\Content.IE5\1ITK5PR2\Setup.exe Name: Trojan-Downloader.Win32.FraudLoad.wmxc There is 1 object reported as infected by it. I hope that I have been thorough enough. Any help would be greatly appreciated! Thank you.